Endocrine Abstracts

Background: Before radioiodine (RAI) therapy patients undergo a technetium 99m thyroid uptake scan and anti-thyroid medication is stopped prior to treatment following clinical review with the nuclear medicine team. Once treated, patients are followed up in the post-radioiodine telephone clinic. Thyroid function is checked at 3, 6, 9 and 12 weeks. Levothyroxine is started once the fT4 is <14 pmol/l.Purpose: To assess ...

Background: Peptide-receptor-radionuclide-therapy (PRRT) improves progression free survival in metastatic neuroendocrine neoplasia (NEN). To be suitable for PRRT, somatostatin receptor-2 (SSTR2) must be present on tumour site as determined by positive uptake on [68Ga]Ga-DOTA-peptide-PET/CT. LANTana is an ongoing study evaluating whether treatment with the demethylating agent, ASTX727, results in re-expression of SSTR2, as determined by [68Ga]Ga-DOTA-peptide-PE...

Case History: A 47 year-old female was referred to the Endocrine Bone Unit with worsening back, rib and leg pain associated with significantly reduced mobility. In the preceding year, she had repeatedly presented to healthcare providers with no clear neurological deficit, no fractures identified on X-Ray and normal MRI appearances of the whole spine. Aside from well-controlled asthma and gestational diabetes, she had no significant past medical, medication, social or family hi...